Could Sensory Mechanisms Be a Core Factor That Underlies Freezing of Gait in Parkinson’s Disease?
Identifieur interne : 000E18 ( Main/Exploration ); précédent : 000E17; suivant : 000E19Could Sensory Mechanisms Be a Core Factor That Underlies Freezing of Gait in Parkinson’s Disease?
Auteurs : Kaylena A. Ehgoetz Martens [Canada] ; Frederico Pieruccini-Faria [Canada] ; Quincy J. Almeida [Canada]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
English descriptors
- KwdEn :
- Analysis of Variance, Darkness, Feedback, Sensory (physiology), Freezing Reaction, Cataleptic (physiology), Gait Disorders, Neurologic (etiology), Gait Disorders, Neurologic (physiopathology), Humans, Models, Biological, Ontario, Parkinson Disease (complications), Parkinson Disease (physiopathology).
- MESH :
- geographic : Ontario.
- complications : Parkinson Disease.
- etiology : Gait Disorders, Neurologic.
- physiology : Feedback, Sensory, Freezing Reaction, Cataleptic.
- physiopathology : Gait Disorders, Neurologic, Parkinson Disease.
- Analysis of Variance, Darkness, Humans, Models, Biological.
Abstract
The main objective of this study was to determine how manipulating the amount of sensory information available about the body and surrounding environment influenced freezing of gait (FOG), while walking through a doorway. It was hypothesized that the more limited the sensory information, the greater the occurrence of freezing of gait. Nineteen patients with Parkinsoǹs disease who experience freezing of gait (PD-FOG) walked through a doorway or into open space in complete darkness. The three doorway conditions included: (i) FRAME (DARK) – walking through the remembered door frame; (ii) FRAME - walking through the door with the door frame illuminated; (iii) FRAME+BODY - walking through the door (both the door and the limbs illuminated). Additionally, two conditions of walking away from the doorway included: (iv) NO FRAME (DARK) - walking into open space; (v) NO FRAME+BODY - walking into open space with the limbs illuminated, to evaluate whether perception (or fear) of the doorway might account for FOG behaviour. Key outcome measures included: the number of freezing of gait episodes recorded, total duration of freezing of gait, and the percentage of time spent frozen. Significantly more freezing of gait episodes occurred when participants walked toward the doorway in complete darkness compared to walking into open space (p<0.05). Similar to previous studies, velocity (p<0.001) and step length (p<0.0001) significantly decreased when walking through the door in complete darkness, compared to all other conditions. Significant increases in step width variability were also identified but only when walking into open space (p<0.005). These results support the notion that sensory deficits may have a profound impact on freezing of gait that need to be carefully considered.
Url:
DOI: 10.1371/journal.pone.0062602
PubMed: 23667499
PubMed Central: 3648560
Affiliations:
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Ehgoetz Martens</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Psychology, University of Waterloo, Waterloo, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Psychology, University of Waterloo, Waterloo, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Sun Life Financial Movement Disorders Research and Rehabilitation Centre, Wilfrid Laurier University, Waterloo, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Sun Life Financial Movement Disorders Research and Rehabilitation Centre, Wilfrid Laurier University, Waterloo, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Pieruccini Faria, Frederico" sort="Pieruccini Faria, Frederico" uniqKey="Pieruccini Faria F" first="Frederico" last="Pieruccini-Faria">Frederico Pieruccini-Faria</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Sun Life Financial Movement Disorders Research and Rehabilitation Centre, Wilfrid Laurier University, Waterloo, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Sun Life Financial Movement Disorders Research and Rehabilitation Centre, Wilfrid Laurier University, Waterloo, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Almeida, Quincy J" sort="Almeida, Quincy J" uniqKey="Almeida Q" first="Quincy J." last="Almeida">Quincy J. Almeida</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Sun Life Financial Movement Disorders Research and Rehabilitation Centre, Wilfrid Laurier University, Waterloo, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Sun Life Financial Movement Disorders Research and Rehabilitation Centre, Wilfrid Laurier University, Waterloo, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance</term><term>Darkness</term><term>Feedback, Sensory (physiology)</term><term>Freezing Reaction, Cataleptic (physiology)</term><term>Gait Disorders, Neurologic (etiology)</term><term>Gait Disorders, Neurologic (physiopathology)</term><term>Humans</term><term>Models, Biological</term><term>Ontario</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (physiopathology)</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Ontario</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Gait Disorders, Neurologic</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Feedback, Sensory</term><term>Freezing Reaction, Cataleptic</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Gait Disorders, Neurologic</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Darkness</term><term>Humans</term><term>Models, Biological</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The main objective of this study was to determine how manipulating the amount of sensory information available about the body and surrounding environment influenced freezing of gait (FOG), while walking through a doorway. It was hypothesized that the more limited the sensory information, the greater the occurrence of freezing of gait. Nineteen patients with Parkinsoǹs disease who experience freezing of gait (PD-FOG) walked through a doorway or into open space in complete darkness. The three doorway conditions included: (i) FRAME (DARK) – walking through the remembered door frame; (ii) FRAME - walking through the door with the door frame illuminated; (iii) FRAME+BODY - walking through the door (both the door and the limbs illuminated). Additionally, two conditions of walking away from the doorway included: (iv) NO FRAME (DARK) - walking into open space; (v) NO FRAME+BODY - walking into open space with the limbs illuminated, to evaluate whether perception (or fear) of the doorway might account for FOG behaviour. Key outcome measures included: the number of freezing of gait episodes recorded, total duration of freezing of gait, and the percentage of time spent frozen. Significantly more freezing of gait episodes occurred when participants walked toward the doorway in complete darkness compared to walking into open space (p<0.05). Similar to previous studies, velocity (p<0.001) and step length (p<0.0001) significantly decreased when walking through the door in complete darkness, compared to all other conditions. Significant increases in step width variability were also identified but only when walking into open space (p<0.005). These results support the notion that sensory deficits may have a profound impact on freezing of gait that need to be carefully considered.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Henderson, Jm" uniqKey="Henderson J">JM Henderson</name></author><author><name sortKey="Watson, S" uniqKey="Watson S">S Watson</name></author><author><name sortKey="Halliday, Gm" uniqKey="Halliday G">GM Halliday</name></author><author><name sortKey="Heinemann, T" uniqKey="Heinemann T">T Heinemann</name></author><author><name sortKey="Gerlach, M" uniqKey="Gerlach M">M Gerlach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martens, Dj" uniqKey="Martens D">DJ Martens</name></author><author><name sortKey="Whishaw, Iq" uniqKey="Whishaw I">IQ Whishaw</name></author><author><name sortKey="Miklyaeva, Ei" uniqKey="Miklyaeva E">EI Miklyaeva</name></author><author><name sortKey="Pellis, Sm" uniqKey="Pellis S">SM 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Ehgoetz Martens</name></noRegion><name sortKey="Almeida, Quincy J" sort="Almeida, Quincy J" uniqKey="Almeida Q" first="Quincy J." last="Almeida">Quincy J. Almeida</name><name sortKey="Ehgoetz Martens, Kaylena A" sort="Ehgoetz Martens, Kaylena A" uniqKey="Ehgoetz Martens K" first="Kaylena A." last="Ehgoetz Martens">Kaylena A. Ehgoetz Martens</name><name sortKey="Pieruccini Faria, Frederico" sort="Pieruccini Faria, Frederico" uniqKey="Pieruccini Faria F" first="Frederico" last="Pieruccini-Faria">Frederico Pieruccini-Faria</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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